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Parathyroid Hormone and T‐Cellular Immunity in Uremic Patients in Replacement Dialytic Therapy
Author(s) -
Angelini Daniela,
Carlini Antonio,
Giusti Riccardo,
Grassi Riccardo,
Mei Ermenegildo,
Fiorini Italbo,
Mazzotta Luisa,
Antonelli Alessandro
Publication year - 1993
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1993.tb00415.x
Subject(s) - cd8 , parathyroid hormone , medicine , endocrinology , immunity , hormone , cellular immunity , hyperparathyroidism , cd4 cd8 ratio , chemistry , immune system , immunology , calcium , lymphocyte subsets
We studied 54 patients in replacement dialytic therapy divided into two groups: Group 1, 26 patients with normal parathyroid hormone (PTH) (10–80 pg/ml); and Group 2, 28 patients with elevated PTH (80–400 pg/ml). Total T lymphocytes, CD4, CD8, and CD4/CD8 ratio were evaluated. We found a reduction of total T lymphocytes in both groups compared with controls. A decrease of CD4 and CD4/CD8 ratio with a rise of CD8 occurred in Group 2 but not in Group 1. In Group 2, PTH presented a linear correlation with CD8 and a reverse correlation with total T cells, CD4, and CD4/CD8 ratio. PTH might act on T‐cellular immunity with an immunosuppressive effect from the earlier phases of hyperparathyroidism.