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Peritoneal Dialysis for the Removal of Protein‐Bound Markers of Hepatic Insufficiency
Author(s) -
Sarnatskaya V.V.,
Nikolaev V.G.,
Osipova L.A.,
Ivanov A.I.,
Maslenny V.N.,
Ivanyuk A.A.,
Yushko L.A.
Publication year - 1993
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1993.tb00390.x
Subject(s) - ultrafiltration (renal) , peritoneal dialysis , albumin , dialysis , bilirubin , adsorption , chemistry , serum albumin , obstructive jaundice , jaundice , medicine , human serum albumin , chromatography , urology , organic chemistry
The addition of human serum albumin (HSA) to peritoneal dialysate increases the clearance of bilirubin in rats suffering from obstructive jaundice. The acceptor properties of the fluid can be enhanced by using HSA that does not contain standard stabilizing additives and has been purified by further adsorption on activated carbon. Bilirubin‐containing dialysate fluid, as well as the ascitic fluid of cirrhotic patients, can be regenerated by a combination of membrane ultrafiltration and carbon adsorption. These observations suggest a potentially useful scheme for continuous, regenerative peritoneal dialysis in the treatment of hepatic insufficiency.