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Analysis of Phosphate Kinetics in Hemofiltration and Hemodiafiltration: Formulation of an Efficiency Index
Author(s) -
Maurizio Nordio,
Giannino De Cecco,
Fabio Mirandoli,
Giovanni Cocco,
Cristina Lombini,
Laura Guarda,
Pietro Marchini,
Santino Lorenzi,
Silvio Giove,
Carla Nardelli
Publication year - 1993
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1993.tb00380.x
Subject(s) - hemofiltration , kinetics , compartment (ship) , exponential function , chemistry , mathematics , medicine , surgery , physics , hemodialysis , geology , mathematical analysis , oceanography , quantum mechanics
The kinetics of phosphate (P) during a treatment of hemofiltration or hemodiafiltration follows a simple exponential law, and P in 90 min reaches a stationary level that remains constant until the end of the treatment. The theoretical compartmental model cannot be estimated by a dialytic treatment, but a simpler diffusive model may be considered. Once the stationary level is reached, the net flux of P from the inaccessible compartments to the accessible compartment may be estimated via the parameters obtained in the exponential model. Hemodiafiltration seems more efficient than hemofiltration in determining P clearance. Thus an efficiency index that accounts for the period in which P is eliminated from the accessible compartment has been formulated.