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Adsorption of Nafamostat Mesilate by Hemodialysis Membranes
Author(s) -
Inagaki Oshi,
Nishian Yoshihiko,
Iwaki Ryotaro,
Nakagawa Kiyohiko,
Takamitsu Yoshihiro,
Fujita Yosikazu
Publication year - 1992
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1992.tb00551.x
Subject(s) - membrane , polyacrylonitrile , adsorption , chemistry , cationic polymerization , polymer chemistry , chromatography , nuclear chemistry , organic chemistry , biochemistry , polymer
The adsorption of the anticoagulant nafamostat mesilate (FUT‐175) by five different hemodialysis membranes was studied in vivo and in vitro. In vivo, FUT‐175 was adsorbed strongly by a polyacrylonitrile (AN69) membrane and slightly by another polyacrylonitrile (J‐PAN) membrane but not by Cuprophan (CU), hemophan (HE), or polymethylmethacrylate (PMMA) membranes during hemodialysis performed in 4 patients in whom FUT‐175 was used as an anticoagulant. Only during hemodialysis using the AN69 membrane did FUT‐175 not induce a significant prolongation of celite‐activated coagulation time. In vitro studies showed that FUT‐175 was adsorbed by the AN69, J‐PAN, and PMMA membranes but not by the CU and HE membranes. Methylene blue, a dye that possesses a cationic portion in its chemical structure, stained AN69, J‐PAN, and PMMA membranes. Since FUT‐175 also possesses a cationic portion, we conclude that FUT‐175 is adsorbed by negatively charged membranes via an ionic bond and is unsuited for use as an anticoagulant in hemodialysis using an AN69 membrane because of that membrane's marked capacity to adsorb FUT‐175.