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Effect of Hemodialysis on T Lymphocyte Subsets, Con‐A‐Activated Suppressor Cell Activity, and Interleukin‐2 Receptor Expression on Lymphocytes in Chronic Uremic Patients
Author(s) -
Tchórzewski Henryk,
Luciak Marek,
Trznadel Kazimierz,
Majewska Ewa,
Pokoca Lech
Publication year - 1989
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1989.tb02861.x
Subject(s) - suppressor , receptor , interleukin 2 , immune system , lymphocyte , hemodialysis , endocrinology , receptor expression , t lymphocyte , stimulation , medicine , t cell , cell , mixed lymphocyte reaction , immunology , chemistry , biochemistry , cancer
Effect of hemodialysis (HD) on some indices of immune response was studied in nine chronic uremics. Total lymphocyte, OKT4 +, and OKT8+ cell numbers significantly decreased during the first 20 min of HD, and they were decreased till the third hour of the procedure, whereas the OKT4 +/OKT8 + cell number ratio did not change significantly. Before HD, Con‐A‐activated suppressor cells exerted a stimulatory action on autologous responder cells measured in two‐step culture. During HD, Con‐A‐activated suppressor cell activity transiently appeared, with its peak at 60 min after the start of HD. It was accompanied by a transient rise in lymphocyte count with spontaneous interleukin‐2 (IL‐2) receptor expression, whereas the number of cells expressing IL‐2 receptor following phytohemaglutinin (PHA) stimulation was progressively decreased during HD. A significant correlation was found between the increment of Con‐A‐activated suppressor cell activity and the increment of spontaneous IL‐2 receptor expression on lymphocytes during one single blood flow through the dialyzer. The results supply further evidence that HD may impose additional disturbances on immune regulation in chronic uremics.