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Effects of Bicarbonate‐Containing versus Lactate‐Containing Peritoneal Dialysis Solutions on Superoxide Production by Human Neutrophils
Author(s) -
Manahan Ferdinand J.,
Ing Brian L.,
Chan Joseph C.,
Gupta Dinesh K.,
Zhou FangQiang,
Pal Indra,
Rahman Mohamed A.
Publication year - 1989
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1989.tb01568.x
Subject(s) - superoxide , peritoneal dialysis , bicarbonate , chemistry , dialysis , biochemistry , medicine , enzyme
Human neutrophils were isolated from healthy volunteers and exposed to either bicarbonate‐containing (pH 7.4) or lactate‐containing (pH 5.2) peritoneal dialysis solution in vitro. Superoxide production by neutrophils was measured by a method based on the superoxide dis‐mutase‐inhibitable reduction of ferricytochrome c. Bicarbonate‐containing peritoneal dialysis solution was found to be superior to the lactate‐containing one in facilitating the production of superoxide anion by human neutrophils.