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Improved Biocompatibility by Modified Cellulosic Membranes: The Case of Hemophan
Author(s) -
Lucchi Leonardo,
Bonucchi Decenzio,
Acerbi Maria Angela,
Cappelli Gianni,
Spattini Andrea,
Innocenti Maurizio,
Castellani Alfonso,
Lusvarghi Egidio
Publication year - 1989
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1989.tb01550.x
Subject(s) - biocompatibility , in vivo , chemistry , membrane , cellulose acetate , chemiluminescence , in vitro , biocompatible material , dialysis tubing , cellulosic ethanol , nuclear chemistry , dialysis , cellulose , biochemistry , chromatography , biomedical engineering , surgery , medicine , biology , organic chemistry , microbiology and biotechnology
The rising problem of biocompatibility is encouraging the development of new dialysis membranes, but the high cost of synthetic ones precludes their wide use. The authors compared the biocompatibility of cu‐prophan (CU), cellulose acetate (CA), and hemophan (HE), evaluating both in vitro and in vivo polymorpho‐nuclear leukocyte (PMN) oxidative metabolism activation by resting chemiluminescence and complement activation by C3a; in vivo PMN counts during dialysis were also performed. The lowest increase in in vitro PMN resting chemiluminescence using HE was +71.3% with CA, + 49.3% with CU, and +21.4% with HE (p < 0.001 versus CA and CU); furthermore, HE did not significantly stimulate PMN resting chemiluminescence during in vivo hemodialysis: +56.6% with CA, +38.8% with CU, and + 3.7% with HE (p < 0.01 versus CU and p < 0.001 versus CA). C3a concentration increased with all membranes both in vitro and in vivo, but HE (in both experimental conditions) showed the lowest increase at any time (p < 0.001 versus CA and CU). After 15 min of dialysis, PMN count dropped to 20.3% of basal values with CU, to 49.8% with CA, and to 76.5% with HE (p < 0.001 versus CU and CA). Among cellulosic membranes, HE is the most biocompatible and appears to be an important step in preventing blood‐membrane interactions and related complications.