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Complement Activation Produced by Biomaterials
Author(s) -
Chenoweth Dennis E.
Publication year - 1988
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1988.tb02815.x
Subject(s) - anaphylatoxin , biocompatible material , complement system , complement (music) , membrane , chemistry , materials science , biomedical engineering , immunology , medicine , biochemistry , complementation , gene , phenotype , antibody
: The complement‐activating potential of biomaterials may be defined by appropriate application of C3a and C5a anaphylatoxin radioimmunoassays. Studies performed with hemodialysis membranes demonstrate that blood contact with these model biomaterials results in complement activation that may be ascribed to specific properties of the material surface. Further delineation of these chemical and physical properties may permit design of biocompatible materials.