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Cefoperazone in the Treatment of Peritonitis in Continuous Ambulatory Peritoneal Dialysis Patients
Author(s) -
Leehey David J.,
Reid Ralston,
Chan Alex Y.,
Ing Todd S.
Publication year - 1988
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1988.tb02808.x
Subject(s) - cefoperazone , continuous ambulatory peritoneal dialysis , peritonitis , medicine , peritoneal dialysis , antibiotics , cephalosporin , cephalosporin antibiotic , ambulatory , gastroenterology , microbiology and biotechnology , antibiotic resistance , biology , imipenem
Cefoperazone is a third‐generation cephalosporin that is active against a broad spectrum of gram‐positive and gram‐negative bacteria. We added this antibiotic to peritoneal dialysis solution at a concentration of 62.5 mg/L to treat peritonitis in six continuous ambulatory peritoneal dialysis (CAPD) patients. Serum drug concentrations were obtained at 0, 0.5, 1, 2, 4, and 24 h after instituting antibiotic therapy. Rapid uptake by blood of the antibiotic across the peritoneal membrane occurred when the latter was inflamed. Adequate bactericidal serum levels for many bacteria were obtained in less than 4 h. Cefoperazone effectively eradicated peritonitis in all patients.