Premium
Rapid Measurement of Dialzyer Clearance as a Function of Molecular Weight
Author(s) -
Klein Elias,
Turnham Timothy J.,
Ward Richard A.
Publication year - 1988
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1988.tb02767.x
Subject(s) - function (biology) , medicine , biology , microbiology and biotechnology
The relationship between solute clearance and molecular weight (MW) is an important performance characteristic of hemodialyzers. Traditionally, this relationship has been determined using a range of solutes of diverse properties that require a variety of analytical procedures. We describe a simple method for obtaining clearance as a function of MW using a homologous series of glucose oligomers, continuous from the monomer to the octamer. Using HPLC, single analyses of the inflow and outflow streams of the dialyzer allow the determination of clearances over a MW range of up to 1314 daltons.