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Development of Extrauterine Fetal Incubation System Using Extracorporeal Membrane Oxygenator
Author(s) -
Kuwabara Yoshinori,
Okai Takashi,
Imanishi Yukio,
Muronosono Etsuo,
Kozuma Shiro,
Takeda Satoru,
Baba Kazunori,
Mizuno Masahiko
Publication year - 1987
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1987.tb02663.x
Subject(s) - fetus , oxygenator , umbilical vein , extracorporeal , extracorporeal membrane oxygenation , medicine , amniotic fluid , membrane oxygenator , extracorporeal circulation , anesthesia , obstetrics , surgery , pregnancy , chemistry , cardiopulmonary bypass , biology , biochemistry , genetics , in vitro
Despite the recent progress in perinatal medicine, it is still difficult to manage the extremely immature newborn. A new extrauterine incubation system has been developed using 14 goat fetuses. The goat fetus is surrounded by artificial amniotic fluid and is connected to an extracorporeal membrane oxygenator. The blood is drained from the umbilical arteries and returned to the umbilical vein. The perfused blood is recirculated and ventilated with a mixture of O 2 , N 2 , and CO 2 gases to obtain a Po 2 of 30–35 mm Hg and a P co2 of 30–35 mm Hg in the umbilical venous blood. Fetal heart rate, blood pressure, electroencephalogram, and several movement parameters are continuously recorded by the polygraph. With this system, the fetuses can be kept under fairly stable physiological conditions for periods up to 165 h. This improved system might therefore become a useful method to manage the ill fetuses and newborns.