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A Model of Ultrafiltration and Glucose Mass Transfer Kinetics in Peritoneal Dialysis
Author(s) -
Jaffrin M. Y.,
Odell R. A.,
Farrell P. C.
Publication year - 1987
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1987.tb02660.x
Subject(s) - ultrafiltration (renal) , chemistry , dwell time , mass transfer , peritoneal dialysis , chromatography , volume (thermodynamics) , continuous ambulatory peritoneal dialysis , dialysis , glycerol , permeation , membrane , urology , surgery , biochemistry , medicine , thermodynamics , clinical psychology , physics
We have investigated the variation with dwell time of dialysate volume and glucose concentration during continuous ambulatory peritoneal dialysis using a one‐pool model. No assumption was made regarding the ultrafiltration rate that was calculated by the model. Results show that the volume ultrafiltered during dwell time is an increasing function of peritoneal membrane hydraulic permeability and a decreasing function of glucose mass transfer coefficient (MTC). For large MTC and low initial glucose concentration there is reabsorption of dialysate into the blood at large dwell times. For a 6 h dwell time, glycerol (92 daltons) is a more effective osmotic agent than glucose (198 daltons) at the same weight concentration. These results are in quantitative agreement with published clinical studies.