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Dialyzer Reuse Following Manual Reprocessing with a New Sterilant, RenNew‐D
Author(s) -
Gag Raymonde,
Adkar Vinita,
Kaye Michael
Publication year - 1987
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1987.tb02644.x
Subject(s) - reuse , dialysis , biocompatibility , chemistry , biomedical engineering , medicine , surgery , waste management , engineering , organic chemistry
Dialysis patients are at risk for toxicity from formaldehyde used in the reprocessing of dialyzers for reuse; therefore, replacing formaldehyde as a dialyzer sterilant would be advantageous. The potential for RenNew‐D as a sterilizing agent was investigated in seven stable in‐center hemodialysis patients over 20 consecutive dialyses with cuprammonium cellulose hollow‐fiber dialyzers. Treatment with RenNew‐D showed no toxicity to patients or dialyzers except for two blood leaks occurring in one patient. The mean number of dialyzer uses was 4.9. In all the dialyzers that passed functional testing small solute clearances were maintained with reuse. The ability of RenNew‐D to improve the bio‐compatibility of reused dialyzers was documented with mean neutrophil counts falling to only 78% of initial values during first reuse of dialyzers processed with RenNew‐D compared with a decrease in neutrophil count to 2% of initial values during first use of the same dialyzers. Our results suggest that RenNew‐D may be a useful alternative to formaldehyde for the purpose of dialyzer reuse. A reuse procedure that includes processing with RenNew‐D is associated with improved biocompatibility, possibly because of maintenance of the blood‐derived membrane coating established during prior dialysis.