Premium
Antibody Responses to Hemodialysis‐Related Antigens in Chronic Hemodialysis Patients
Author(s) -
Dolovich Jerry,
Evans Susan,
Baurmeister Ulrich,
Schulze Helmut,
Ali Mohammed,
Shimizu Arthur
Publication year - 1987
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1987.tb02636.x
Subject(s) - antibody , antigen , immunology , hemodialysis , immunoglobulin e , sensitization , formaldehyde , chemistry , serum albumin , bovine serum albumin , medicine , biochemistry
Allergic‐type reactions during hemodialysis are sometimes due to sensitization to ethylene oxide. To examine the possibility that additional antigens might be a basis for unexplained reactions, antibodies to formaldehyde and phthalte‐related antigens and to dialyzer extracts were measured. Unselected sera from 113 chronic hemodialysis patients (CHP) and 200 control subjects were tested for IgG antibodies to formaldehyde‐treated human serum albumin (HSA). The IgG antibody activity was confirmed in sera of five CHP who had used formaldehyde‐treated dialyzers. These antibodies also reacted with formaldehyde‐treated red blood cells. Sera from 71 CHP and 80 controls were tested for IgE antibodies to diethylphthalate‐treated HSA; antibody was detected in two CHP sera. With extracts from hollow‐fiber dialyzers, IgG antibody was detected in ˜1/3 and IgM antibodies in ˜1/2 of CHP sera. This antibody was found in comparable numbers of control sera. It was concluded that these additional substances are immunogenic and could be involved in allergic‐type reactions.