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Topographic and Dynamic Radioisotopic Investigations of Interactions Between Biomaterials and Blood Components
Author(s) -
Baquey Charles,
BasseCathalinat Bernard,
Bordenave Laurence,
Caix Josseline,
Brendel André Jacques,
Ducassou Dominique
Publication year - 1986
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1986.tb02608.x
Subject(s) - adsorption , adhesion , protein adsorption , fibrinogen , chemistry , platelet , biomedical engineering , in vivo , blood clotting , desorption , materials science , nanotechnology , biochemistry , organic chemistry , engineering , microbiology and biotechnology , immunology , biology
Functional investigations using radionuclides to study protein adsorption and platelet adhesion onto biomaterials are described. The authors' novel methods use radiotracers with a dynamic technique. This allows direct observation of the interaction between blood, or simpler biological substances, and artificial materials. Several radiotracers were used in this study, including 111 In‐platelets, 123 I‐fibrinogen, 123 I‐antithrombin HI, and 99m Tc‐tagged red blood cells. The detectors employed were a semiconductor diode or gamma‐camera equipped with special collimators. The acquisition and treatment of data were performed with an original device. These methods allowed precise comparisons, especially between platelet adhesion upon different materials in the form of tubes and also protein adsorption and desorption. The results are discussed in terms of materials to be used for work in vivo.