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Comparison of Four Methods of Cleaning Hollow‐Fiber Dialyzers for Reuse
Author(s) -
Dennis Melvin B.,
Vizzo Joseph E.,
Cole James J.,
Westendorf Diane L.,
Ahmad Suhail
Publication year - 1986
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1986.tb02602.x
Subject(s) - volume (thermodynamics) , ultrafiltration (renal) , urea , chemistry , sodium hydroxide , reuse , creatinine , chromatography , fiber , hydrogen peroxide , pulp and paper industry , biomedical engineering , waste management , medicine , biochemistry , engineering , organic chemistry , physics , quantum mechanics
Four methods of cleaning hollow‐fiber artificial kidneys (HFAKs) for reuse were compared in a prospective study. Each cleaning method was randomly assigned and HFAKs were reused until volume loss was ≥15 ml, unless discarded for other reasons. HFAKs cleaned with 0.3 M sodium hydroxide averaged 14.5 uses, significantly better (p < 0.01) than reverse ultrafiltration (6.4 uses), 3% hydrogen peroxide (5.7 uses), or water flush (4.7 uses). Only 1 of 10 HFAKs cleaned with NaOH was discarded owing to volume loss, whereas 25 of 30 HFAKs cleaned by the other methods were rejected for this reason. To relate changes in solute clearance to volume loss, urea and creatinine clearances were determined on HFAKs cleaned by water flush. By the fifth use the average volume had declined to 86.3% of original, but creatinine and urea clearances were reduced, respectively, to 97 and 95% of the original values.