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Hemodiafiltration Treatment of Deep Hepatic Coma by Protein Passing Membrane: Case Report
Author(s) -
Yoshiba Makoto,
Yamada Haruki,
Yoshikawa Yuji,
Fujiwara Kenji,
Toda Gotaro,
Oka Hiroshi,
Sanjo Takamasa,
Yamazaki Zenya,
Idezuki Yasuo,
Inoue Noboro,
Sakai Yoshitada,
Kunitomo Tetsunosuke
Publication year - 1986
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1986.tb02590.x
Subject(s) - fulminant hepatic failure , hepatic coma , coma (optics) , membrane , fulminant , medicine , artificial liver , liver failure , chemistry , surgery , biochemistry , liver transplantation , physics , transplantation , optics
Based on the assumption that middle molecules that induce hepatic coma occur in the plasma of patients with fulminant hepatic failure (FHF), the authors have developed a hemodiafiltration (HDF) method using a large-pore poly(methylmethacrylate) (PMMA) membrane that allows proteins to pass through. PMMA HDF resulted in complete recovery of deep coma and long-term survival in a patient with severe FHF. Although a large-scale controlled trial is needed, PMMA HDF is believed to be promising as a future artificial liver support.