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Relationship Between Red Blood Cell Lipid Peroxidation, Plasma Hemoglobin, and Red Blood Cell Osmotic Resistance Before and After Vitamin E Supplementation in Hemodialysis Patients
Author(s) -
Lubrano Riccardo,
TacconeGallucci Massimo,
Mazzarella Valentina,
Bandino Donatella,
Citti Giovanni,
Elli Marco,
Giardini Omero,
Casciani Carlo U.
Publication year - 1986
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1986.tb02553.x
Subject(s) - lipid peroxidation , hematocrit , vitamin e , hemoglobin , hemodialysis , red blood cell , hemolysis , anemia , dialysis , medicine , red cell , endocrinology , chemistry , oxidative stress , antioxidant , biochemistry
It has been reported that increased peroxidation of the polyunsaturated fatty acids in the erythrocyte membranes is one of the causes of chronic hemolysis in uremic patients on hemodialysis and that therapeutic doses of vitamin E are effective in reducing peroxidation, improving the hematocrit. The present study shows how the reduced peroxidation, induced by a course with therapeutic doses of vitamin E, is paralleled by a significant reduction of plasma hemoglobin concentrations at the end of the dialysis and by a significant improvement of erythrocyte osmotic resistance. The findings lead to the suggestion that the administration of tocopherol to patients on chronic hemodialysis for end‐stage renal disease may be beneficial in improving anemia, acting via a reduction of lipid peroxidation of the red blood cell membranes. Whether this can reduce the need for the transfusions can be assessed only with a longitudinal long‐term study, which is also necessary to determine whether the preliminary findings of this report have important clinical applications.