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Evaluation of the Thrombogenicity of Selected Microporous Oxygenator Membranes
Author(s) -
Knight Patricia M.,
Lyman Donald J.
Publication year - 1985
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1985.tb04343.x
Subject(s) - thrombogenicity , membrane , microporous material , silicone rubber , materials science , polytetrafluoroethylene , polypropylene , polymer chemistry , fibrin , chemical engineering , platelet , adsorption , silicone , chemistry , biomedical engineering , composite material , medicine , organic chemistry , biochemistry , immunology , engineering
A comparative study of the thrombogenicity of several microporous membranes was performed using an ex vivo system simulating the conditions in an artificial lung. A study of platelet adhesion and adsorbed protein layer indicated that the membranes separated into three groups. Copolyurethane membranes adsorbed very few platelets and appeared to be most compatible; microporous polypropylene and polytetrafluoroethylene membranes were intermediate in their response; silicone rubber and silicone rubber‐coated paper membranes showed numerous platelet clots, often involving neutrophils and fibrin, and were the least blood compatible.