Premium
Immunologic Studies of Hollow‐Fiber Dialyzer Extracts
Author(s) -
Butcher Brian T.,
Reed Margaret A.,
O'Neil Carol E.,
Leech Stephen,
Pearson Frederick C.
Publication year - 1984
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1984.tb04298.x
Subject(s) - chemistry , antibody , hemodialysis , isocyanate , membrane , antigen , immunization , ultrafiltration (renal) , lysis , dialysis , chromatography , immunology , medicine , biochemistry , surgery , organic chemistry , polyurethane
Testing failed to detect free isocyanates in dialyzer rinses or significant levels of immunoglobulin E antibodies to isocyanate‐protein conjugates in the serum of individuals reacting during hemodialysis with dialyzers containing Cuprophan membranes. Extended immunization of rabbits with Limulus lysate‐reactive material from dialyzer rinses demonstrated antigenic activity of the rinse that appears to originate from cotton linters used in hollow‐fiber membranes. The possibility that an immunologic response to these antigens may be a mechanism in adverse reactions to hemodialysis is discussed.