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Ex Vivo Preclinical Evaluation of Membrane Plasma Separators
Author(s) -
Matsubara S.,
Wojcicki J. M.,
Sueoka A.,
Horiuchi T.,
Matsugane T.,
Starre J. J.,
Smith J. W.,
Malchesky R S.,
Nosé Y.
Publication year - 1984
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1984.tb04271.x
Subject(s) - ex vivo , membrane , plasmapheresis , cellulose acetate , thromboelastography , in vivo , white blood cell , chemistry , biomedical engineering , platelet , surgery , materials science , medicine , immunology , biochemistry , biology , in vitro , microbiology and biotechnology , antibody
Four different types of hollow‐fiber membrane plasma separators, constructed of cellulose acetate, polyvinyl alcohol, polyethylene, and polymethylmethacrylate membranes, were evaluated in ex vivo dog perfusions under conditions simulating their clinical use. An arteriovenous (A‐V) fistula constructed in the dogs for blood access enabled repeated access to be achieved without surgical intervention. All modules produced transient leukopenia and a reduction of platelet counts. The polymethylmethacrylate module showed minimum reductions of white blood cell counts and CH 50 . The early leukocyte count reduction in membrane plasmapheresis is most likely related to the magnitude of complement activation by the membrane, as is seen with hemodialysis.