Premium
Leukopenia, Hypoxemia, and Complement Activation During a Single Hemoperfusion
Author(s) -
TacconeGallucci Massimo,
Pericone Roberto,
Carolis Caterina,
Fontana Luigi,
Mazzarella Valentina,
Morosetti Massimo,
Casciani Carlo Umberto
Publication year - 1984
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1984.tb04263.x
Subject(s) - hemoperfusion , leukopenia , hypoxemia , complement system , chemistry , medicine , anesthesia , immunology , toxicity , antibody , hemodialysis
Abstract: White blood cell count, acid‐base balance, Po 2 , and complement function in five uremic patients undergoing a single hemoperfusion employing activated charcoal coated with methacrylate were studied. After 20 min on hemoperfusion, a marked leukopenia [ranging from 6,080±526 to 3,740±1,124 (p<0.02)] and hypoxemia [ranging from 106±13.8 to 80.2±11.9 mm Hg (p<0.02)] were observed. At the same time, total hemolytic complement decreased from 135±15.7 to 123±14.7 U/ml (p< 0.001) and alternative pathway activity from 38.1±5.1 to 33.1±6.7 U/ml (p <0.005). C3 and B cleavage fragments were detected in the samples tested, thus demonstrating the activation of the complement alternative pathway. After 60 min, the different parameters tended to increase but did not reach the baseline levels. A direct correlation between the degree of leukopenia and the reduction of Po 2 throughout the hemoperfusion period was found. pH, Pco 2 , and HCO 3 did not change throughout the hemoperfusion period. The results demonstrate that complement activation, leukopenia, and hypoxemia occur during hemoperfusion.