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Hemoperfusion and DNA Synthesis in the Rat Liver Part II: The Effect of Hemoperfusion on DNA Synthesis in the Rat Liver Undergoing Compensatory Hyperplasia after Partial Hepatectomy
Author(s) -
Ryan Calvin J.,
Courtney James M.,
Blumgart Leslie H.
Publication year - 1982
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1982.tb04081.x
Subject(s) - hemoperfusion , hepatectomy , charcoal , activated charcoal , chemistry , hyperplasia , liver regeneration , anesthesia , medicine , pharmacology , surgery , regeneration (biology) , biology , resection , organic chemistry , hemodialysis , adsorption , microbiology and biotechnology
An investigation has been made into whether hemoperfusion over activated charcoal effects the rate of DNA synthesis in the rat liver undergoing compensatory hyperplasia. Hemoperfusion was performed in the unrestrained and conscious rat, thus minimizing any possible effects of stress and eliminating exposure to anesthetic agents. The results demonstrate that hemoperfusion over Norit RBX1 charcoal does not influence the liver to undergo compensatory hyperplasia following partial hepatectomy when hemoperfusion is performed immediately after hepatic injury, and that liver mass, function, and fat content consequent upon partial hepatectomy are also not influenced.