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A Reciprocating, Single‐Needle Hemodialyzer with Bidirectional Flow of Sorbent Suspension
Author(s) -
Barile Ronald G.,
Wang NienHwa L.,
Blake Donald E.,
Belcastro Patrick F.,
Gupta Shri,
Regnier Fred E.,
Thornhill Jerry A.,
Kessler David P.,
Ash Stephen R.
Publication year - 1982
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1982.tb01672.x
Subject(s) - chemistry , sorbent , creatinine , urea , chromatography , bicarbonate , membrane , renal function , reciprocating motion , urology , adsorption , medicine , biochemistry , mechanical engineering , organic chemistry , engineering , gas compressor
Previous theoretical analysis has indicated that adequate mass transfer is possible in a dialyzer with reciprocating membrane motion provided that the dialysate concentration of uremic substances is kept low. Earlier models have utilized a collection of sorbents (charcoal, urease, and a cation exchanger) constrained next to the dialyzer membranes. We have designed a new dialyzer with a sorbent suspension having free access from a reservoir to the spaces between membrane packages. At a treatment rate of 150 ml/min/m 2 , the in vitro creatinine clearance is 75 ml/min/m 2 , which agrees within experimental accuracy with the theoretical prediction. The creatinine clearance, flow resistance, and compliance of the dialyzer are constant during four to six hours of testing. In vivo tests have been performed during urea and creatinine infusion in a normal dog and in a dog with 3/4 nephrectomy. The in vivo creatinine clearance agrees within 10% with the in vitro clearance. Sodium, potassium, calcium, and bicarbonate fluxes are acceptable for patients in renal failure. The new design allows a higher capacity for urea and creatinine, since larger amounts of sorbent may be used.