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Acid Citrate Dextrose Reduces Platelet Retention During In Vitro and In Vivo Dog Hemoperfusion: A Comparative Study of Different Charcoal Adsorbers
Author(s) -
Tangerman Albert,
Snel Pleun,
Schaik Annie,
Tongeren Jan H.M.
Publication year - 1981
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1981.tb04017.x
Subject(s) - hemoperfusion , activated charcoal , chemistry , charcoal , in vivo , platelet , in vitro , pharmacology , chromatography , biochemistry , medicine , adsorption , surgery , immunology , biology , microbiology and biotechnology , hemodialysis , organic chemistry
Hemoperfusion through charcoal adsorbers has often been proposed for use in exogenous and endogenous intoxication. A serious drawback of this technique is the often encountered loss of platelets and leucocytes. In vitro hemoperfusion studies with heparinized human blood and in vivo hemoperfusion of heparinized Labrador dogs through different types of charcoal adsorbers (Becton‐Dickinson [B‐D], Gambro, Haemocol) clearly demonstrated that addition of the anticoagulant acid citrate dextrose (ACD) might reduce the loss of platelets. ACD seemed to have no distinct influence on leucocyte retention.