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Pseudointima in Expanded Polytetrafluoroethylene Graft Implanted in the Inferior Vena Cava of Normal and Defibrinogenated Dogs
Author(s) -
Ishimaru Shin,
WilliamOlsson Eva Berglin,
Hansson HansArne,
TeeferNilsson AnnCatrine,
WilliamOlsson Goran
Publication year - 1981
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1981.tb03976.x
Subject(s) - batroxobin , fibrinogen , thrombus , polytetrafluoroethylene , inferior vena cava , medicine , surgery , vena cava , chemistry , organic chemistry
The pseudointimal formation in an expanded polytetrafluoroethylene graft implanted in the canine inferior vena cava was studied by light and transmission electron microscopy. Five of 6 grafts in the control group and all the 10 grafts in the batroxobin‐defibrinogenated group were patent, and provided for the investigation. The thickness of the mural thrombus formed within 3 days was significantly decreased in the severely defibrinogenated dogs, in which the fibrinogen concentration was below 0.40 gm/L, as compared to the controls and the moderately defibrinogenated dogs, in which the fibrinogen concentration was at highest 0.72‐0.87 gm/L. In spite of reducing the fibrinogen concentration to unmeas‐urable levels after 3 days, there was no obvious difference in the process of pseudointimal formation between the moderately defibrinogenated dogs and the controls. In the severely defibrinogenated dogs, loose and spongoid mural thrombus required a longer time to be reorganized.