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Artificial Excretion of Weakly Bound Middle Molecules by Hemoanadiafiltration
Author(s) -
Russo Luigi,
Russo Anna,
Viola Mario,
Russo Vincenzo
Publication year - 1980
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1980.tb03898.x
Subject(s) - ultrafiltration (renal) , molecule , chemistry , biochemistry , organic chemistry
The concept of a subtractive therapeutic intervention in several diseases (shock, acute liver, failure, poisoning) to remove toxic middle molecules (MM) has led to the devising of a particular ultrafiltration system (anadiafiltration) to clear weakly bound MM. Clinical hemoanadiafiltration (HADF) with a polyacrylonitrile filter and in vitro experiments with a series of marker substances, have shown HADF efficacy in clearing MM, irrespective of their molecular weight, with protein binding K between 60 and 150.