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High‐Permeability Membrane Hemodialysis and Hernofiltration in Acute Hepatic Coma: Experimental and Clinical Results
Author(s) -
Opolon Pierre
Publication year - 1979
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1979.tb01077.x
Subject(s) - hemodialysis , fulminant hepatic failure , coma (optics) , medicine , polyacrylonitrile , fulminant , hemofiltration , permeability (electromagnetism) , membrane , gastroenterology , surgery , chemistry , biochemistry , liver transplantation , physics , organic chemistry , transplantation , optics , polymer
A high‐permeability polyacrylonitrile membrane was used for hemodialysis in experimental animals with induced liver ischemia and for acute treatment of 39 patients with fulminant hepatic failure. Measurements were made of amino acids and other relevant compounds; nine patients survived. In long‐term studies, the polyacrylonitrile membrane was used for hemofiltration in ten clinical cases of fulminant hepatic failure and coma. Five patients, including two pregnant women, survived.