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Problems with Activated Charcoal and Alumina as Sorbents for Medical Use
Author(s) -
Maeda Kenji,
Saito Akira,
Kawaguchi Shunsuke,
Sezaki Rhozo,
Niwa Toshimitsu,
Naotsuka Masaaki,
Kobayashi Kaizo,
Asada Hiroaki,
Yamamoto Yukio,
Ohta Kazuhiro
Publication year - 1979
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1979.tb01073.x
Subject(s) - activated charcoal , charcoal , adsorption , activated carbon , chemistry , phosphate , chromatography , creatinine , nuclear chemistry , inorganic chemistry , organic chemistry , biochemistry
Although activated charcoal and alumina have been used extensively as sorbents in uremic patients, the following problems remain to be solved: 1) elution of SO, 4 ‐ from activated charcoal which does not adsorb it; 2) production of methylguanidine from creatinine on the surface of activated charcoal; 3) production of lipoperoxide from fatty acids by chemical reaction of activated charcoal; 4) adsorption of Ca ++ and Mg ++ when alumina adsorbs inorganic phosphate. These problems are studied in vitro and clinically.