Premium
Counterregulatory System in an Artificial Endocrine Pancreas Glucose Infusion Algorithm
Author(s) -
Yamasaki Yoshimitsu,
Shichiri Motoaki,
Kawamori Ryuzo,
Goriya Yoshikazu,
Sasai Tomonori,
Morishima Toyohiko,
Nomura Makoto,
Tohdo Ryohei,
Abe Hiroshi
Publication year - 1979
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1979.tb01061.x
Subject(s) - endocrine system , artificial pancreas , pancreas , endocrinology , medicine , algorithm , diabetes mellitus , computer science , hormone , type 1 diabetes
An artificial endocrine pancreas has been developed by adding a glucose infusion system to the artificial beta cell system. In this computer algorithm, glucose is infused on the basis of proportional and derivative actions to blood glucose concentration with the time delay constant between blood withdrawal and initiation of glucose infusion. When glucose was infused on the basis of proportional action with a 20‐minute time delay, the prompt restoration to normoglycemia from the hypoglycemic state with a smaller amount of glucose was shown in depancreatized dogs. These results indicate that the artificial endocrine pancreas thus prepared is not only a useful device to safely control blood glucose, but also is an efficient research tool for the analysis of the blood glucose regulatory mechanism.