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Mass Transfer Characteristics of Hollow‐Fiber Dialyzers and Hemoperfusion Devices
Author(s) -
Cooney David O.,
Daly John S.
Publication year - 1979
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1979.tb01059.x
Subject(s) - hemoperfusion , fiber , mass transfer , materials science , biomedical engineering , chemistry , chromatography , composite material , medicine , surgery , hemodialysis
Clearance versus time tests were carried out on three charcoal‐based hemoperfusion devices (Sandev, Becton‐Dickinson and Gambro) using solutions of 1 gm/L sodium salicylate in a pH 7.4 buffer and in bovine blood at flow rates of 200 rnl/min. Similar tests were performed on a Cordis Dow 2.5 m 2 hollow‐fiber dialyzer at a tube side flow rate (Qb) of 200 ml/min. Buffer was pumped through the dialysate side at a flow rate (Q d ) of 400 ml/min. Two dialyzers were run in series at Q b = 200 ml/min and Qd = 500 or 1000 ml/min. Mass transfer resistances were computed from the test results. These values are useful in that they constitute an index of the intrinsic initial kinetics of solute transfer in each device. However, the clearance versus time curves indicate that these initial kinetics decrease at different rates for each hemoperfusion unit as sorption capacity begins to be depleted. In contrast, the initial clearances for the dialyzers remain at their initial values. These data reveal much about the relative mass transfer characteristics of these devices.