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Ultrastructural Characteristics of Dog and Human Platelets Adherent to Native and Collagen‐Coupled Cuprophan
Author(s) -
Lewis Jon C.,
Didisheim Paul,
Grabowski Eric F.,
Mann Kenneth G.
Publication year - 1979
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1979.tb01033.x
Subject(s) - platelet , degranulation , pseudopodia , cytoplasm , chemistry , adhesion , ultrastructure , dense granule , biophysics , platelet adhesion , platelet adhesiveness , platelet activation , immunology , anatomy , biology , platelet aggregation , biochemistry , cell , receptor , organic chemistry
Adhesion of human and dog platelets to native and collagen‐coupled Cuprophan under defined flow conditions was studied by scanning and transmission electron microscopy. Dog platelets, singly adherent to and uniformly distributed on both native and collagen‐coupled Cuprophan, extend slender pseudopods across the surface without evidence of degranulation. Human platelets, while not adhering to native Cuprophan, formed irregularly shaped, semi‐confluent cytoplasmic sheets on the collagen‐coupled surface. Extensive cytoplasmic reorganization and degranulation suggests a post‐release state of the human platelets. Aspirin had no apparent effect on either human or dog platelet adhesion or upon the apparent release state of the human platelets.