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Clearance of Meprobamate by Hemoperfusion Over Columns of Charcoal and Amberlite Resin
Author(s) -
Hoy Wendy,
Schwab Gary,
Freeman Richard B.
Publication year - 1978
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1978.tb01629.x
Subject(s) - hemoperfusion , meprobamate , extraction (chemistry) , amberlite , chemistry , chromatography , charcoal , activated charcoal , perfusion , medicine , pharmacology , surgery , adsorption , organic chemistry , hemodialysis
Perfusion of the blood of a patient with toxic levels of meprobamate through an activated charcoal cartridge resulted in efficient early clearance of the drug, then a decline in extraction. Perfusion through a resin column resulted in total drug extraction without a decline in clearance over four hours. Both procedures were stable with minimal disturbance in hematological values or blood chemistries. This is the first report of in vivo hemoperfusion over resin for meprobamate poisoning. The efficacy and safety of the procedure need emphasis.