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Mathematical and Experimental Methods for Design and Evaluation of Membrane Oxygenators
Author(s) -
Eberhart Robert C.,
Dengle Satish K.,
Curtis Robert M.
Publication year - 1978
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1978.tb00999.x
Subject(s) - membrane oxygenator , oxygenator , flow (mathematics) , current (fluid) , computer science , mechanics , mechanical engineering , materials science , engineering , thermodynamics , medicine , surgery , physics , extracorporeal membrane oxygenation , cardiopulmonary bypass , anesthesia
Three categories of membrane oxygenators are considered: passive flow, secondary flow induced by the mainstream, secondary flow induced by an external application of energy. The current status of mathematical methods for analysis of fluid mechanics, O 2 and CO 2 exchange for these categories are briefly reviewed. Emphasis is given to approximate methods for calculation of gas exchange. Practical methods for experimental design optimization studies are outlined; these methods are extended to evaluation of O 2 and CO 2 exchange in clinical operation. A new method for estimation of internal ventilation and perfusion maldistribution and diffusion resistance is described. A brief assessment of blood damage in clinical application of the oxygenator is presented from the point of view of deterioration of gas exchange performance.