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Successful Combination Treatment of a Patient with Progressive Juvenile Localized Scleroderma (Morphea) Using Imatinib, Corticosteroids, and Methotrexate
Author(s) -
Inamo Yasuji,
Ochiai Toyoko
Publication year - 2012
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2012.01882.x
Subject(s) - medicine , methotrexate , morphea , scleroderma (fungus) , imatinib , localized scleroderma , dermatology , imatinib mesylate , prednisone , connective tissue disease , calcipotriol , psoriasis , surgery , disease , pathology , autoimmune disease , inoculation , lichen sclerosus , myeloid leukemia
We report a case of progressive juvenile localized scleroderma ( JLS or morphea) treated with a combination of imatinib, corticosteroids, and methotrexate. This therapy halted the progressive skin thickening and the hand and finger joint deformity in the early stages of the disease. We conclude that imatinib used in addition to standard treatment with systemic corticosteroids and methotrexate may be of therapeutic benefit for individuals with JLS .