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Recurrence of Cutaneous Necrosis in an Infant with Probable Catastrophic Antiphospholipid Syndrome
Author(s) -
CamachoLovillo Soledad,
BernabeuWittel Jose,
IglesiasJimenez Estíbaliz,
FalcónNeyra Doloresm,
Neth Olaf
Publication year - 2012
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2012.01832.x
Subject(s) - medicine , catastrophic antiphospholipid syndrome , rituximab , antiphospholipid syndrome , presentation (obstetrics) , pediatrics , dermatology , surgery , immunology , thrombosis , antibody
We present the case of a 3‐month‐old child with probable catastrophic antiphospholipid syndrome who, after initial successful management with immunomodulary therapies including rituximab, experienced a cutaneous relapse. This rare event was successfully re‐treated with repeated administration of rituximab, supporting its role in the control of this disorder. Dermatologic manifestations may be the main clinical presentation of antiphospholipid syndrome, a possible underdiagnosed but potentially fatal pathology.