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Fatal Paraneoplastic Pemphigus After Removal of Castleman’s Disease in a Child
Author(s) -
Daneshpazhooh Maryam,
Moeineddin Fatemeh,
Kiani Amin,
Naraghi Zahra S.,
Firooz Alireza,
Akhyani Maryam,
ChamsDavatchi Cheyda
Publication year - 2012
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2011.01670.x
Subject(s) - medicine , paraneoplastic pemphigus , bronchiolitis obliterans , prednisolone , pemphigus , azathioprine , dermatology , respiratory failure , bronchiolitis , disease , castleman disease , respiratory system , surgery , pathology , lung , immunology , autoantibody , antibody , lung transplantation
Paraneoplastic pemphigus (PNP) is seen most frequently in the setting of Castleman’s disease (CD) in childhood. We report herein a 10‐year‐old girl with PNP appearing a few weeks after resection of a recurrent CD. Despite improvement in skin and mucosal lesions with prednisolone and azathioprine, she had severe bronchiolitis obliterans and died from respiratory failure a few months later.