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A Challenging Case: Symmetrical Drug Related Intertriginous and Flexural Exanthem, Fixed Drug Eruption, or Both?
Author(s) -
Özkaya Esen,
Babuna Goncagül
Publication year - 2011
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2011.01656.x
Subject(s) - intertriginous , medicine , drug eruption , dermatology , amoxicillin , patch test , acute generalized exanthematous pustulosis , exanthem , drug , pathology , allergy , antibiotics , immunology , pharmacology , disease , microbiology and biotechnology , biology
We herein report a 12‐year‐old boy with amoxicillin‐induced, recurrent, site‐specific, symmetrical, sharply demarcated reddish plaques on the buttocks and the major flexural and intertriginous areas. The lesions resolved with topical corticosteroids, leaving hyperpigmentation. Histopathology showed nonspecific features of inflammation and dermal melanophages. Amoxicillin was the probable inducer based on oral provocation test with Amoksina ® tablet, however patch testing with amoxicillin on previously affected and unaffected skin remained negative. The diagnosis was challenging because of the overlapping features of symmetrical drug‐related intertriginous and flexural exanthema and fixed drug eruption. This one represents a unique and challenging one with overlapping clinical features of symmetrical drug‐related intertriginous and flexural exanthem (SDRIFE) and fixed drug eruption (FDE). We discuss the possible immunopathogenetic mechanisms leading to the simultaneous occurrence of different phenotypes of drug eruption in the same patient.