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Clear‐Cell Papulosis: A Rare Entity That May Be Misconstrued Pathologically as Normal Skin
Author(s) -
Wysong Ashley,
Sundram Uma,
Benjamin Latanya
Publication year - 2011
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2011.01614.x
Subject(s) - medicine , biopsy , skin biopsy , girl , dermatology , pathology , histopathological examination , psychology , developmental psychology
We describe a case of multiple, discrete, hypopigmented macules in the suprapubic and axillary region in a healthy 3‐year‐old girl. The lesions first appeared at approximately 9 months of age and increased in number over time. Initial histopathologic examination by an outside dermatopathologist at 1 year of age was reported as showing nonspecific histologic changes. A repeat biopsy at 3 years of age showed large intraepidermal clear cells that expressed CKAE1/CAM5.2, CK7, and BRST2. These findings are diagnostic for clear‐cell papulosis, a rare condition that primarily affects children. Without great clinical and pathologic suspicion, this is a diagnosis that can often be overlooked because the histologic findings are virtually identical to those of normal skin.