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Childhood Epidermolysis Bullosa Acquisita: Report of a Chinese Case
Author(s) -
Yang Baoqi,
Wang Chong,
Wang Na,
Pan Futang,
Chen Shengli,
Zhou Guizhi,
Yu Meiling,
Zhang Furen
Publication year - 2011
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2011.01509.x
Subject(s) - epidermolysis bullosa acquisita , medicine , dapsone , anchoring fibrils , epidermolysis bullosa , dermatology , direct fluorescent antibody , histopathology , cicatricial pemphigoid , autoantibody , pathology , prednisone , pemphigoid , bullous pemphigoid , immunology , antibody , basement membrane , surgery
Epidermolysis bullosa acquisita (EBA) is a rare, acquired, subepidermal blistering disease characterized by autoantibodies directed against type VII collagen, the major component of anchoring fibrils. We report a 5‐year‐old Chinese boy who presented with extensive lesions consisting of disseminated pruritic vesicles and tense blisters. The diagnosis of EBA was confirmed by histopathology, immunofluorescence, and immunoblotting analysis. The disease was controlled with a combination of prednisone and dapsone.