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Hydroa Vacciniforme‐like Epstein–Barr Virus‐associated Lymphoproliferative Disease: A Case Report
Author(s) -
Zeng Yueping,
Fu Lanqin,
Jin Hongzhong,
Sun Qiuning,
Wang Baoxi
Publication year - 2011
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2011.01399.x
Subject(s) - medicine , dermis , epstein–barr virus , skin biopsy , pathology , virus , biopsy , infiltration (hvac) , immunohistochemistry , immunology , physics , thermodynamics
We report a case of hydroa vacciniforme‐like skin eruptions with chronic active Epstein–Barr virus infection in a 16‐year‐old boy. The patient had repeated episodes of vesiculo‐necrotic eruptions on the face, trunk, and extremities for 13 years. General symptoms included fever, splenomegaly, and abnormal liver function. Histopathological examination of skin biopsy specimen demonstrated dense infiltration of lymphocytes, histocytes, and some neutrophils and plasma cells in the dermis. Immunohistochemical stain revealed that the lymphocytes were positive for T cell and B cell markers. Epstein–Barr virus infection studies and systemic presentation confirmed the diagnosis.