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Spitz Nevi Arising in Speckled Lentiginous Nevus: Clinical, Histologic, and Molecular Evaluation of Two Cases
Author(s) -
Torti Dorothea C.,
Brennick Jeoffry B.,
Storm Craig A.,
Dinulos James G.H.
Publication year - 2011
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2011.01239.x
Subject(s) - medicine , spitz nevus , dermatology , pathology , hyperpigmentation , nevus , immunohistochemistry , melanocytic nevus , melanoma , cancer research
Spitz nevi are small dome‐shaped nodules that sometimes arise in areas of preexisting hyperpigmentation, such as a speckled lentiginous nevus (nevus spilus), where they present a diagnostic dilemma. We report clinical, histopathological, and molecular findings of two cases of multiple Spitz nevi arising in a speckled lentiginous nevus. We used immunohistochemistry to assess expression of Ki‐67, epidermal growth factor receptor, vascular endothelial growth factor, and RelA in two cases of Spitz nevi arising in a speckled lentiginous nevus. We observed rare staining for the proliferative marker Ki‐67, but positive staining for the growth and antiapoptotic factors epidermal growth factor receptor, vascular endothelial growth factor, and RelA. Characterization of the molecular phenotype of Spitz nevi arising in speckled lentiginous nevi may provide a useful adjunct to long‐term monitoring in this rare but difficult clinical presentation.