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Plexiform Fibrohistiocytic Tumor with Molecular and Cytogenetic Analysis
Author(s) -
LeclercMercier Stéphanie,
Pedeutour Florence,
Fabas Thibault,
Glorion Christophe,
Brousse Nicole,
Fraitag Sylvie
Publication year - 2011
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2010.01370.x
Subject(s) - comparative genomic hybridization , fluorescence in situ hybridization , pathology , cytogenetics , medicine , molecular cytogenetics , biopsy , in situ hybridization , karyotype , biology , chromosome , genetics , gene , gene expression
A child with plexiform fibrohistiocytic tumor is presented, in whom a superficial biopsy was misdiagnosed as an inflammatory granuloma. Cytogenetic analysis revealed a 46,X,del(X)(q13)[3]/46,XX[23] karyotype. However, fluorescence in situ hybridization (FISH) and array‐comparative genomic hybridization (CGH) analysis failed to detect any numerical or quantitative genomic anomaly. Because of lack of specific chromosomal hallmarks, a molecular diagnosis of plexiform fibrohistiocytic tumor with the currently available tools is not reliable.