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Congenital Lupus Erythematosus Presenting at Birth with Widespread Erosions, Pancytopenia, and Subsequent Hepatobiliary Disease
Author(s) -
LYNN CHENG C.,
GALBRAITH SHEILA,
HOLLAND KRISTEN
Publication year - 2010
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2009.01057.x
Subject(s) - medicine , pancytopenia , transplacental , lupus erythematosus , systemic lupus erythematosus , dermatology , connective tissue disease , disease , pathology , autoimmune disease , fetus , immunology , pregnancy , antibody , placenta , bone marrow , biology , genetics
Neonatal lupus erythematosus is an uncommon disease caused by transplacental passage of maternal anti‐Ro (SS‐A), anti‐LA (SS‐B), or anti‐U1RNP antibodies. Cutaneous findings of neonatal lupus are variable, but annular, erythematous plaques occurring within a few weeks of birth are most typical. Cutaneous lesions of congenital onset lupus erythematosus can differ from that of neonatal lupus erythematosus, presenting with atrophy or scarring, and less commonly, erosions. We report an unusual case of congenital lupus erythematosus presenting at birth with widespread erosions, pancytopenia, and subsequent hepatobiliary disease.