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Allopurinol‐Induced DRESS Syndrome in an Adolescent Patient
Author(s) -
Dewan Ashvin K.,
Quiz Ricardo A.
Publication year - 2009
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2009.00983.x
Subject(s) - medicine , allopurinol , leukocytosis , eosinophilia , methylprednisolone , emergency department , etiology , dermatology , pediatrics , surgery , psychiatry
A 16‐year‐old male patient, with a history of essential hypertension enrolled in an experimental drug protocol using allopurinol, presented to our emergency department with a 10‐day history of fever. Initial laboratory evaluation revealed leukocytosis, eosinophilia, and transaminitis. After extensive work‐up and exclusion of infectious and oncologic etiologies, the diagnosis of allopurinol‐induced drug reaction and eosinophilia with systemic symptoms syndrome was carried out. The patient responded to administration of IV methylprednisolone, with complete resolution of symptoms and improvement of laboratory abnormalities. This case represents the first report of allopurinol‐induced drug reaction and eosinophilia with systemic symptoms syndrome in a pediatric patient.