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A Case of S‐100‐Positive Juvenile Xanthogranuloma: A Longitudinal Observation
Author(s) -
YAMAMOTO YOSUKE,
KADOTA MASAFUMI,
NISHIMURA YOUICHI
Publication year - 2009
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2009.00959.x
Subject(s) - juvenile xanthogranuloma , juvenile , medicine , longitudinal study , dermatology , pathology , histiocyte , biology , genetics
We present the case of a 9‐month‐old boy with yellow‐brown papules that gradually increased in number over a period of 6 months without systemic involvement. Our case was clinicopathologically diagnosed as S‐100‐positive juvenile xanthogranuloma, and longitudinal observation revealed that strong S‐100 reactivity disappeared in parallel with maturation of the lesions within 2 years after the initial diagnosis. These findings add to the complexity in cells of origin of this disorder.