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Multiple Pilomatricomas and Gliomatosis Cerebri—A New Association?
Author(s) -
WachterGiner Tina,
Bieber Imke,
WarmuthMetz Monika,
Bröcker EvaB.,
Hamm Henning
Publication year - 2009
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2008.00827.x
Subject(s) - medicine , myotonic dystrophy , gardner syndrome , oxcarbazepine , dermatology , pathology , rubinstein–taybi syndrome , familial adenomatous polyposis , epilepsy , carbamazepine , cancer , colorectal cancer , psychiatry
Pilomatricomas are benign skin tumors originating from hair follicle matrix cells. In 2% to 3.5% of cases they occur in multiplicity and then may be associated with genetic diseases, such as myotonic dystrophy Curschmann–Steinert, familial adenomatous polyposis (Gardner syndrome), and Rubinstein–Taybi syndrome. A 15‐year‐old boy treated with temozolomide and oxcarbazepine for gliomatosis cerebri with symptomatic epilepsy developed four firm cutaneous nodules on his face and right upper arm in the course of 1 year. All four tumors were excised under local anesthesia. Histological examination confirmed the clinical diagnosis of pilomatricomas. This is the first published case of a patient suffering from gliomatosis cerebri and developing multiple pilomatricomas. Whether this observation represents a new association or is a mere coincidence cannot be clarified at present.