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Acral Erythema with Oral Methotrexate in a Child
Author(s) -
Varela Carly R.,
McNamara Joseph,
Antaya Richard J.
Publication year - 2007
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2007.00513.x
Subject(s) - medicine , methotrexate , erythema , dermatology , chemotherapy , lymphoblastic leukemia , acute lymphocytic leukemia , erythema multiforme , leukemia
Acral erythema is a rare cutaneous reaction that has been associated with various chemotherapy regimens. Most occurrences have been described in adult patients. Recently, methotrexate has been implicated in the development of acral erythema; however, pediatric reports are few. All of the reports in the pediatric and adult literature have described patients receiving moderate to high‐dose intravenous methotrexate. Here, we describe an instance of standard‐dose oral methotrexate‐associated acral erythema in a young girl with acute lymphoblastic leukemia, and review the recent literature as it relates to pediatric patients.