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Clinical Resolution of a Neonatally Eroded Giant Congenital Melanocytic Nevus
Author(s) -
Gass Julia K.,
Grant John W.,
Hall Per N.,
Atherton David J.,
Burrows Nigel P.
Publication year - 2006
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2006.00311.x
Subject(s) - histology , medicine , nevus , congenital melanocytic nevus , melanocytic nevus , dermatology , biopsy , pathology , skin biopsy , melanin , connective tissue , melanoma , biology , cancer research , genetics
We report an unusual occurrence of spontaneous pigmentary regression with a desmoplastic reaction in a neonatally eroded giant congenital melanocytic nevus. This process has been documented with photographs and skin biopsy specimens. Neonatal histology demonstrated connective tissue proliferation. Histology at age 5 years also demonstrated a very high proportion of amelanotic dermal nevus cells. Regression of pigmentation in our patient may be due to a decrease in melanin production by dermal nevus cells rather than a decrease in their number.