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Subcutaneous Panniculitis‐like T‐Cell Lymphoma in a 26‐Month‐Old Child with a Review of the Literature
Author(s) -
Yim Jun Hee,
Kim MiYeon,
Kim Hyung Ok,
Cho Bin,
Chung NakGyun,
Park Young Min
Publication year - 2006
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2006.00305.x
Subject(s) - medicine , panniculitis , pathology , lymphoma , vincristine , cyclophosphamide , cutaneous lymphoma , subcutaneous tissue , chop , histiocyte , prednisolone , cd20 , chemotherapy , mycosis fungoides
Subcutaneous panniculitis‐like T‐cell lymphoma is a rare cytotoxic T‐cell lymphoma of the skin that preferentially infiltrates the subcutaneous tissue. We report here this lymphoma occurring in a 26‐month‐old Korean girl. She presented with multiple erythematous subcutaneous nodules on both extremities and her back along with systemic symptoms. She had a protracted course of multiple erythematous subcutaneous nodules for 1 month and a spiking fever was often noted. The histopathologic findings for the subcutaneous nodules were lobular panniculitis‐like material that was composed of atypical lymphocytes and histiocytes. The atypical lymphocytes characteristically rimmed individual fat cells in a lace‐like pattern and some of the histiocytes showed phagocytosed white blood cells occasionally. Immunophenotypic studies showed CD3 + , CD45RO + , CD20 − , CD4 − , CD8 + , and CD56 − . She is currently being treated with combination chemotherapy of cyclophosphamide, doxorubicin, vincristine, and prednisolone.